Assessment of Micronutrients in Children With Malaria Infection

Assessment of Micronutrients in Children With Malaria Infection

Content Structure of Assessment of Micronutrients in Children With Malaria Infection

• The abstract contains the research problem, the objectives, methodology, results, and recommendations
• Chapter one of this thesis or project materials contains the background to the study, the research problem, the research questions, research objectives, research hypotheses, significance of the study, the scope of the study, organization of the study, and the operational definition of terms.
• Chapter two contains relevant literature on the issue under investigation. The chapter is divided into five parts which are the conceptual review, theoretical review, empirical review, conceptual framework, and gaps in research
• Chapter three contains the research design, study area, population, sample size and sampling technique, validity, reliability, source of data, operationalization of variables, research models, and data analysis method
• Chapter four contains the data analysis and the discussion of the findings
• Chapter five contains the summary of findings, conclusions, recommendations, contributions to knowledge, and recommendations for further studies.
• References: The references are in APA
• Questionnaire

Abstract of Assessment of Micronutrients in Children With Malaria Infection

The increased clinical state of malaria infection may be due to poor nutritional status most especially as a result of micronutrients deficiency. Micronutrients play vital role both in combating anaemia and other adverse effects of malaria infection in humans and animals in developing resistance against the disease. This research was aimed at establishing the effect of malaria parasite on neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and some essential plasma electrolytes (calcium, magnesium and iron) as well as vitamins (vitamin B₁₂ and folate) of children. Ethical approval was gotten from ministry of Health, Benin City, Edo State. Test group was recruited from the paediatric ward of Central Hospital, Benin City. A questionnaire, written in English was administered to the parents of the subjects to fill. An informed consent was given to the parents or guardian of the children before sample was collected Blood sample was collected from two hundred (n = 200) children within the ages of l – 10 years as test group who are positive for malaria parasites while the control group were one hundred (100) children above l0yrs of age who do not have malaria parasites. Thick blood film was used to ascertain the level of parasitaemia using giemsa stain, vitamin B₁₂ was done using electroluminescence technique, folic acid was analysis was done using ELISA technique, while iron, magnesium and calcium was spectrophotometrically analyzed. Results gotten in this research shows that PCV decreased significantly compared to the control group, (p<0.05). White blood cell increased (p<0.05) compared to the control, Plasma calcium, magnesium and iron decreased significantly; there was decrease in folate and vitamin B₁₂. Micronutrients are not only necessary in the regeneration of heamolyzed red cells during malaria infection, but also served as antioxidants hence protecting the red cells against damage by malaria toxins. It is therefore of tremendous importance to assess micronutrients status of children with malaria.

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